Furthermore, in-vivo results indicated that decursin strongly inhibits selective neuronal death, astrogliosis, and oxidative stress induced by KA administration. The decursin-treated KA-injected group showed significantly decreased behavioral seizure activity and remarkably attenuated intense and high-frequency seizure discharges in the parietal cortex for 2 h compared with the group treated only with KA. KA injections significantly enhanced neurodegenerative conditions but treatment with decursin 30 min before KA injection reduced the detrimental effects of KA in mice. Thirty minutes after intraperitoneal injections of decursin (20 mg/kg) in male 7-week-old C57BL/6 mice, the animals were treated with KA (30 mg/kg, intraperitoneally) and then examined for behavioral seizure score, electroencephalogram, seizure-related expressed protein levels, neuronal cell loss, neurodegeneration, and astrogliosis. This study served to investigate the effects of decursin on a kainic acid ( KA)-induced status epilepticus model. Of the coumarin derivatives in Angelica gigas, decursin, a major coumarin component, was reported to exhibit significant protective activity against glutamate- induced neurotoxicity when added to primary cultures of rat cortical cells. Lee, Jong-Keun Jeong, Ji Woon Jang, Taeik Lee, Go-Woon Han, Hogyu Kang, Jae-Seon Kim, Ik-HwanĮpilepsy is a neurological disorder with recurrent unprovoked seizures as the main symptom. I appreciate your efforts and apologize for any inconvenience.Decursin attenuates kainic acid-induced seizures in mice. An informed citizenry is a fundamental requirement for our democracy to work. Thank you for your interest in reading the law. You may find more information on our activities at Public Resource Please read my testimony before the United States Congress. For more information on edicts of government and your rights as a citizen under the rule of law, To apply for a license to read this law, please consult the Code of Federal Regulations or applicable state laws and regulationsįor the name and address of a vendor. Your right to read and speak the laws by which we choose to govern ourselves as a democratic society. Your access to this document, which is a law of the United States of America, has been temporarily disabled while we fight for (Public Resource),ĭCD 1:13-cv-01215, United District Court for the District of Columbia To find out more information please see the docket for this pending court case:Īmerican Society for Testing and Materials (ASTM), National Fire Protection Association (NFPA),Īnd American Society of Heating, Refrigerating, and Air-Conditioning Engineers (ASHRAE) v. Public Resource is litigating for your right to read and speak the law. You have been temporarily denied permission to access this document at this time. This Document Is Not Currently Available To You! United States Status Code 451: Your Request Has Been Denied Around the seal is a red circular band with white type that reads on the top half "The Creat Seal of the Seal of Approval" and on the bottom half "" On the outside of the red circular brand is a round silver circular band with scalloped edges, meant to evoke a silver foil seal. The Logo of The logo features a black and white line drawing of a smiling seal with whiskers.
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